Table 4A.

Treatment Details.

Patient No.	Duration to start treatment (weeks)	Treatment of antifungal drug and dose (/day)		Acute phase treatment period (weeks)	Relapse	Additional treatment after relapse (/day)	Intrathecal injection
1	4	①	L-AMB 6 mg/kg 5-FC 100 mg/kg	8	(+)	Restart intrathecal injection ITCZ →VRCZ (dose is unknown)	AMPH-B 0.5 mg (increasing from 0.05 mg)
		②	FLCZ/VRCZ/ITCZ (each dose was unknown)
2	6	①	FLCZ 400 mg (10 mg/kg)	33	(-)	(-)	(-)
		②	L-AMB 100-180 mg (2.5-4.5 mg/kg) 5-FC 4,000 mg (100 mg/kg)
		③	FLCZ 100-400 mg
3	1	①	L-AMB 250 mg (4.38 mg/kg), 5-FC 3,000 mg (≒50 mg/kg)	4	(+)	L-AMB 325 mg (5.8 mg/kg) VRCZ 800 mg	AMPH-B 0.5 mg (increasing from 0.05 mg)
		②	FLCZ 200 mg
4	8	①	L-AMB 350 mg (6 mg/kg) 5-FC 8,000 mg (137 mg/kg)	6	(-)	(-)	AMPH-B 0.45 mg (increasing from 0.05 mg)
		②	FLCZ 800 mg
5	4	①	L-AMB 200 mg (5 mg/kg) 5-FC 6,000 mg (150 mg/kg) VRCZ 300 mg	6	(-)	(-)	(-)
		②	FLCZ 200-400 mg
6	4	①	L-AMB 150 mg (3.3 mg/kg) 5-FC 5,000 mg (110 mg/kg)	3	(-)	(-)	(-)
		②	FLCZ 400 mg
7	4	①	L-AMB 100 mg (2.5 mg/kg) 5-FC 4,000 mg (100 mg/kg)	4	(+)	L-AMB 100 mg (2.5 mg/kg)	(-)
		②	FLCZ 200 mg
8	4	①	L-AMB 150 mg (3.4 mg/kg) 5-FC 4,000 mg (≒100 mg/kg)	9	(+)	L-AMB 150-300 mg 5-FC 4,000 mg (≒ 100 mg/kg) →FLCZ 800 mg 5-FC 4,000 mg (≒ 100 mg/kg)	AMPH-B 1.0 mg (increasing from 0.25 mg)
		②	FLCZ 400 mg
9	9	①	L-AMB 250 mg (6 mg/kg) 5-FC 2,000 mg (50 mg/kg)	4	(+)	L-AMB 200-250 mg →VRCZ 200 mg	(-)
		②	FLCZ 200 mg

L-AMB: liposomal amphotericin B, 5-FC: 5-Fluorocytosine, FLCZ: fluconazole, VRCZ: voriconazole, ITCZ: itraconazole, AMPH-B: amphotericin B