Table 3.
Host factors are independently associated with vaginal community state types in pregnancy.
| Model 1 (n = 680) | Model 2 (n = 680) | Model 3 (n = 680) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR diverse CST | 95% CI | p-value | OR L. iners CST | 95% CI | p-value | OR diverse CST | 95% CI | p-value | OR L. iners CST | 95% CI | p-value | OR diverse CST | 95% CI | p-value | OR L. iners CST | 95% CI | p-value | |
| White | ||||||||||||||||||
| No | – | – | – | – | – | – | – | – | – | – | – | – | ||||||
| Yes | 0.21 | 0.14, 0.32 | < 0.001 | 0.28 | 0.19, 0.42 | < 0.001 | 0.33 | 0.20, 0.55 | < 0.001 | 0.43 | 0.28, 0.68 | < 0.001 | 0.48 | 0.28, 0.82 | 0.007 | 0.61 | 0.38, 0.99 | 0.046 |
| Maternal age | 0.91 | 0.87, 0.96 | < 0.001 | 0.92 | 0.88, 0.96 | < 0.001 | 0.97 | 0.92, 1.02 | 0.2 | 0.97 | 0.93, 1.02 | 0.3 | ||||||
| Education level | ||||||||||||||||||
| BA or higher | – | – | – | – | ||||||||||||||
| HS/GED | 3.48 | 1.73, 6.99 | < 0.001 | 3.71 | 1.92, 7.17 | < 0.001 | ||||||||||||
| Less than HS | 8.46 | 2.60, 27.6 | < 0.001 | 6.17 | 1.91, 19.9 | 0.002 | ||||||||||||
| Some college/assoc | 2.58 | 1.43, 4.67 | 0.002 | 4.01 | 2.36, 6.82 | < 0.001 | ||||||||||||
| Parity category | ||||||||||||||||||
| 1 + | ||||||||||||||||||
| 0 | ||||||||||||||||||
| Antibiotics ever in pregnancy | ||||||||||||||||||
| No | ||||||||||||||||||
| Yes | ||||||||||||||||||
| Model 4 (n = 680) | Model 5 (n = 516) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR diverse CST | 95% CI | p-value | OR L. iners CST | 95% CI | p-value | OR diverse CST | 95% CI | p-value | OR L. iners CST | 95% CI | p-value | |||||||
| White | ||||||||||||||||||
| No | – | – | – | – | – | – | – | – | ||||||||||
| Yes | 0.47 | 0.28, 0.81 | 0.006 | 0.59 | 0.37, 0.97 | 0.036 | 0.7 | 0.34, 1.43 | 0.3 | 0.7 | 0.36, 1.35 | 0.3 | ||||||
| Maternal age | 0.96 | 0.91, 1.01 | 0.12 | 0.96 | 0.91, 1.01 | 0.093 | 0.97 | 0.90, 1.03 | 0.3 | 0.98 | 0.92, 1.05 | 0.6 | ||||||
| Education level | ||||||||||||||||||
| BA or higher | – | – | – | – | – | – | – | – | ||||||||||
| HS/GED | 3.4 | 1.69, 6.84 | < 0.001 | 3.53 | 1.82, 6.86 | < 0.001 | 5.2 | 2.22, 12.2 | < 0.001 | 6.62 | 2.94, 14.9 | < 0.001 | ||||||
| Less than HS | 7.82 | 2.39, 25.6 | < 0.001 | 5.43 | 1.67, 17.6 | 0.005 | 8.84 | 2.46, 31.7 | < 0.001 | 7.81 | 2.21, 27.5 | 0.001 | ||||||
| Some college/assoc | 2.52 | 1.39, 4.57 | 0.002 | 3.86 | 2.26, 6.58 | < 0.001 | 4.18 | 1.88, 9.26 | < 0.001 | 8.44 | 4.06, 17.6 | < 0.001 | ||||||
| Parity category | ||||||||||||||||||
| 1 + | – | – | – | – | – | – | – | – | ||||||||||
| 0 | 0.67 | 0.43, 1.06 | 0.09 | 0.55 | 0.36, 0.84 | 0.006 | 0.68 | 0.38, 1.19 | 0.2 | 0.55 | 0.32, 0.95 | 0.032 | ||||||
| Antibiotics ever in pregnancy | ||||||||||||||||||
| No | – | – | – | – | ||||||||||||||
| Yes | 4.24 | 2.15, 8.35 | < 0.001 | 3.24 | 1.66, 6.30 | < 0.001 | ||||||||||||
OR odds ratio, CI confidence interval, BA or higher college degree or higher, HS/GED high school or general equivalency degree.
Multinomial logistic regression models. Reference is non-L. iners Lactobacillus dominant (I, II, V) community state type.
Model 1 is adjusted for self-identified White race.
Model 2 is adjusted for self-identified White race, host age.
Model 3 is adjusted for self-identified White race, host age, educational attainment.
Model 4 is adjusted for self-identified White race, host age, educational attainment, parity.
Model 5 is adjusted for self-identified White race, host age, educational attainment, parity, and antibiotics use in pregnancy.