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. 2024 May 23;9:88. doi: 10.1038/s41541-024-00877-1

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

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Fig. 5 — Top row: -28D vaccination; middle row: short-course (-3D) vaccination; bottom row: unvaccinated. In unvaccinated (no VRP, given DMEM alone) and short-course-vaccinated animals, CCHFV antigen (red; arrows) was present in scattered cells within the leptomeninges of the brain, ciliary body of the eye, valvular stroma of the heart, adrenal cortex, renal interstitium, pancreatic islets, ovarian follicles and stroma, uterine endometrial stroma, and gastric lamina propria and submucosa/serosa. No immunostaining was seen in the same tissue types from -28D vaccinated animals. Original magnifications: 20 × (heart, kidney, ovary, uterus, stomach); 40 × (brain, eye, pancreas, adrenal); scale bars are 50 μM. CCHFV immunohistochemistry with Fast Red chromogen.