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. 2024 May 23;9:88. doi: 10.1038/s41541-024-00877-1

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

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Fig. 8 — a Anti-NP antibody quality was assessed using an avidity ELISA in which mouse plasma was exposed to varying concentrations of a chaotropic agent (ammonium thiocyanate). Antibody quality was evaluated in plasma from mice vaccinated 28, 14, or 7 days prior to challenge and euthanized 3 dpi. b Antibody-dependent complement deposition (ADCD) assay and (c) antibody-dependent cellular phagocytosis (ADCP) assays were performed using plasma from mice in all vaccine cohorts at 3 and 6 dpi. Fold ADCD activation was calculated using naïve mouse plasma. ADCP phagocytic score was calculated by multiplying the percentage of bead-positive cells by the overall median fluorescence intensity. Data were compared statistically between vaccine groups by timepoint (3 or 6 dpi) using multiple two-tailed t-tests (Mann-Whitney) and only statistically significant results are reported; *p < 0.5, **p < 0.01. Individual animals are represented. Bars and error bars indicate the mean ± standard deviation (SD).