Table 2.

MR sensitivity analyses of between exposures and outcome.

Exposure	Outcomes	Heterogeneity tests		Directional horizontal pleiotropy test
		methods	Cochran’s Q (P)	MR-Egger intercept	Pleiotropy p-value
RA	Osteoporosis (GWAS)	MR-Egger	6.84501 (0.07701)	0.030145	0.75291
		Inverse variance-weighted	7.11648 (0.12986)
	Osteoporosis (Finn)	MR-Egger	4.29157 (0.23165)	0.01607	0.60059
		Inverse variance-weighted	4.77844 (0.31080)
	Osteoporotic fracture	MR-Egger	6.53658 (0.08823)	0.02399	0.75781
		Inverse variance-weighted	6.78512 (0.14769)