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. 2024 May 10;15:1399989. doi: 10.3389/fimmu.2024.1399989

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Copyright © 2024 Bloomfield, Gong, Droho, Makinde, Gurra, Stumpf, Kharel, Gadhvi, Winter, Cui, Cuda and Lavine

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Unintegrated scRNA-seq analysis of brain and eye CD45⁺ immune cells. (A) Dimensionality reduction with uniform manifold approximation and projection (UMAP) for the brain. (B) Canonical marker genes are displayed for brain microglia and macrophage clusters in feature plots. (C) Canonical marker genes are displayed for each cellular cluster in the brain in a dot plot. (D) Dimensionality reduction with UMAP for the eye. (E) Canonical marker genes are displayed for eye microglia and macrophage clusters in feature plots. (F) Canonical marker genes are displayed for each cellular cluster in the eye in a dot plot. Mg, microglia; Mac, macrophage; CM, classical monocyte; NCM, nonclassical monocyte; DC, dendritic cell; PMN, polymorphonuclear neutrophil; NK cell, natural killer cell.