ICB |
immune checkpoint blockade |
ICD |
immunogenic cell death |
RCD |
regulated cell death |
PLK2 |
polo like kinase 2 |
TME |
tumor microenvironment |
TGF-β |
transforming growth factor-β |
DAMPs |
damage-associated molecular patterns |
cDAMPs |
constitutive DAMPs |
iDAMPs |
inducible DAMPs |
CXCL10 |
C-X-C motif chemokine ligand 10 |
PAMPs |
pathogen-associated molecular patterns |
HMGB1 |
nuclear protein high mobility group box 1 |
ATP |
adenosine triphosphate |
APC |
antigen-presenting cell |
DC |
dendritic cell |
TLR |
toll-like receptor |
RAGE |
receptors for advanced glycation end-products |
IL-1 b |
interleukin 1b |
CTL |
cytotoxic T lymphocyte |
CRT |
calreticulin |
MHC |
major histocompatibility complex |
AIM2 |
absent in melanoma 2 |
NK |
natural killer |
LCD |
lysosomal cell death |
ACD |
accidental cell death |
CrmA |
cytokine response modifier A |
TNFα |
tumor necrosis factor-α |
TRAIL |
TNF-related apoptosis-inducing ligand |
FADD |
fas-associated via death domain |
PRR |
pattern recognition receptor |
DAI |
DNA-dependent activator of interferon-regulatory factors |
cGAS |
cyclic GMP-AMP synthase |
RIPK |
receptor-interacting protein kinase |
MLKL |
mixed lineage kinase domain-like pseudokinase |
NNSCC |
head and neck squamous cell carcinoma |
HCC |
hepatocellular carcinoma |
ROS |
reactive oxygen species |
GSH |
glutathione |
SLC7A11 |
solute carrier family 7 member 11 |
GPX4 |
glutathione peroxidase 4 |
RCC |
renal cell carcinoma |
NADPH |
nicotinamide adenine dinucleotide phosphate |
Cu |
Copper |
TCA |
tricarboxylic acid |
DLAT |
dihydrolipoamide S-acetyltransferase |
FDX1 |
ferredoxin 1 |
LIAS |
lipoyl synthase |
TTM |
tetrathiomolybdate |
ER |
endoplasmic reticulum |
NSCLC |
non-small-cell lung cancer |
IGFIR |
insulin-like growth factor I receptor |
PERK |
pancreatic ER kinase (PKR)-like ER kinase |
eIF2α |
eukaryotic translation initiation factor 2α |
ATF4 |
activating transcription factor 4 |
IDO |
indoleamine 2,3-dioxygenase |
PARP1 |
poly (ADP-ribose) polymerase 1 |
AIF |
apoptosis-inducing factor |
MIF |
macrophage migration inhibitory factor |
OSCC |
oral squamous cell carcinoma |
AML |
acute myeloid leukemia |
PDAC |
pancreatic ductal adenocarcinoma |
ATP6V0D1 |
ATPase H+ transporting V0 subunit D1 |
STAT3 |
signal transducer and activator of transcription 3 |
V-ATPase |
vacuolar ATPaseCA9: carbonic anhydrase 9 |
FANCD2 |
FA complementation group D2 |
ACSS2 |
acyl-CoA synthetase short-chain family member 2 |
CQ |
chloroquine |
CAR |
chimeric antigen receptor |
GSDM |
gasdermin |
NLR |
NOD-like receptor |
CDK |
cyclin-dependent kinase |
OSCC |
oral squamous cell carcinoma |
Gzm |
granzyme |
ZBP1 |
Z-form nucleic acid binding protein 1 |
RIG-I |
retinoic acid inducible gene I |
USP18 |
ubiquitin-specific protease 18 |
ISG |
IFN-stimulated gene |
LMP |
lysosomal membrane permeabilization |
NAC |
N-acetylcysteine |