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. 2024 May 10;15:1390263. doi: 10.3389/fimmu.2024.1390263
ICB immune checkpoint blockade
ICD immunogenic cell death
RCD regulated cell death
PLK2 polo like kinase 2
TME tumor microenvironment
TGF-β transforming growth factor-β
DAMPs damage-associated molecular patterns
cDAMPs constitutive DAMPs
iDAMPs inducible DAMPs
CXCL10 C-X-C motif chemokine ligand 10
PAMPs pathogen-associated molecular patterns
HMGB1 nuclear protein high mobility group box 1
ATP adenosine triphosphate
APC antigen-presenting cell
DC dendritic cell
TLR toll-like receptor
RAGE receptors for advanced glycation end-products
IL-1 b interleukin 1b
CTL cytotoxic T lymphocyte
CRT calreticulin
MHC major histocompatibility complex
AIM2 absent in melanoma 2
NK natural killer
LCD lysosomal cell death
ACD accidental cell death
CrmA cytokine response modifier A
TNFα tumor necrosis factor-α
TRAIL TNF-related apoptosis-inducing ligand
FADD fas-associated via death domain
PRR pattern recognition receptor
DAI DNA-dependent activator of interferon-regulatory factors
cGAS cyclic GMP-AMP synthase
RIPK receptor-interacting protein kinase
MLKL mixed lineage kinase domain-like pseudokinase
NNSCC head and neck squamous cell carcinoma
HCC hepatocellular carcinoma
ROS reactive oxygen species
GSH glutathione
SLC7A11 solute carrier family 7 member 11
GPX4 glutathione peroxidase 4
RCC renal cell carcinoma
NADPH nicotinamide adenine dinucleotide phosphate
Cu Copper
TCA tricarboxylic acid
DLAT dihydrolipoamide S-acetyltransferase
FDX1 ferredoxin 1
LIAS lipoyl synthase
TTM tetrathiomolybdate
ER endoplasmic reticulum
NSCLC non-small-cell lung cancer
IGFIR insulin-like growth factor I receptor
PERK pancreatic ER kinase (PKR)-like ER kinase
eIF2α eukaryotic translation initiation factor 2α
ATF4 activating transcription factor 4
IDO indoleamine 2,3-dioxygenase
PARP1 poly (ADP-ribose) polymerase 1
AIF apoptosis-inducing factor
MIF macrophage migration inhibitory factor
OSCC oral squamous cell carcinoma
AML acute myeloid leukemia
PDAC pancreatic ductal adenocarcinoma
ATP6V0D1 ATPase H+ transporting V0 subunit D1
STAT3 signal transducer and activator of transcription 3
V-ATPase vacuolar ATPaseCA9: carbonic anhydrase 9
FANCD2 FA complementation group D2
ACSS2 acyl-CoA synthetase short-chain family member 2
CQ chloroquine
CAR chimeric antigen receptor
GSDM gasdermin
NLR NOD-like receptor
CDK cyclin-dependent kinase
OSCC oral squamous cell carcinoma
Gzm granzyme
ZBP1 Z-form nucleic acid binding protein 1
RIG-I retinoic acid inducible gene I
USP18 ubiquitin-specific protease 18
ISG IFN-stimulated gene
LMP lysosomal membrane permeabilization
NAC N-acetylcysteine