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. 2024 May 10;15:1401214. doi: 10.3389/fimmu.2024.1401214

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Copyright © 2024 Maiorano, Schinzari, Carbone, Piro, Rossi, Di Maio, Di Giacomo and Maiello

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations between baseline IL-2, IFN-γ, IL-6 and IL-8 with avelumab efficacy. (A, D, G, J) ROC curves of baseline levels between responders (Rs) and not-responders (N-Rs) show differences for IL-2, IFN-γ, IL-6, and IL-8. (B, E, H, K) Kaplan-Meier analyses for PFS show a significant impact of threshold values of IL-2, and not significant for IFN-γ, IL-6, and IL-8. (C, F, I, L) Kaplan-Meier analyses for OS show a significant impact of different baseline IL-2, IFN-γ, IL-6, and IL-8 levels.