Table 4.
Sensitivity analysis of hormonal and reproductive factors causally linked to LBP (validation analysis).
| Exposure | Outcome | Pleiotropy | Heterogeneity | ||
|---|---|---|---|---|---|
| Horizontal pleiotropy (Egger intercept) | Horizontal pleiotropy (p-value) | Heterogeneity (Q) | Heterogeneity (p-value) | ||
| ANM | LBP | -1.18E-04 | 0.097 | 112.910 | 0.305 |
| AAM | 4.10E-05 | 0.594 | 256.622 | 0.002 | |
| LMC | 3.97E-05 | 0.899 | 3.281 | 0.657 | |
| AFB | 0.001 | 0.015 | 26.194 | 0.794 | |
| ALB | -9.84E-05 | 0.873 | 6.580 | 0.254 | |
| AFS | -1.79E-05 | 0.873 | 201.169 | 0.259 | |
ANM, age at menopause; AAM, age at menarche; LMC, length of menstrual cycle; AFB, age at first birth; ALB, Age at last live birth; AFS, Age first had sexual intercourse; BMI, Body mass index; LBP, low back pain.