Table 2.
Baseline characteristics of patients included in the FFPE-RNA application cohort.
| Total cohort, n = 104 (%) | Treated group, n = 62 (%) | Control group, n = 42 (%) | P-valuea | |
|---|---|---|---|---|
| Age (years) median (IQR) | 59 (51.0–68.0) | 61.5 (51.8–68.3) | 57 (50.0–67.0) | 0.189 |
| Sex | 0.751 | |||
| Female | 29 (28) | 18 (29) | 11 (26) | |
| Male | 75 (72) | 44 (71) | 31 (74) | |
| Performance status | 0.411 | |||
| 0 | 50 (48.1) | 26 (41.9) | 24 (57.1) | |
| 1 | 19 (18.3) | 11 (17.7) | 8 (19.0) | |
| 2 | 6 (5.8) | 5 (8.1) | 1 (2.4) | |
| 3 | 1 (1.0) | 1 (1.6) | — | |
| Unknown | 28 (26.9) | 19 (30.6) | 9 (21.4) | |
| Specimen | 0.955 | |||
| Biopsy | 35 (33.7) | 21 (33.9) | 14 (33.3) | |
| Resection | 69 (66.3) | 41 (66.1) | 28 (66.7) | |
| Sidedness | 0.568 | |||
| Left | 86 (82.7) | 53 (85.5) | 33 (78.6) | |
| Right | 16 (15.4) | 8 (12.9) | 8 (19.0) | |
| Unknown | 2 (1.9) | 1 (1.6) | 1 (2.4) | |
| Metastases | 0.001 | |||
| Synchronous | 90 (86.5) | 48 (77.4) | 42 (100) | |
| Metachronous | 13 (12.5) | 13 (21.0) | — | |
| Unknown | 1 (1) | 1 (1.6) | ||
| Metastases location | ||||
| Liver | 92 (88.5) | 57 (91.9) | 35 (83.3) | 0.218 |
| Lung | 38 (36.5) | 32 (51.6) | 6 (14.3) | <0.001 |
| Peritoneum | 26 (25.0) | 16 (25.8) | 10 (23.8) | 0.817 |
| Lymph nodes | 38 (36.5) | 25 (40.3) | 13 (31.0) | 0.330 |
| Bone | 11 (10.6) | 10 (16.1) | 1 (2.4) | 0.047 |
| Other | 18 (17.3) | 14 (22.6) | 4 (9.5) | 0.084 |
| Number of metastases | <0.001 | |||
| 0-1 | 47 (45) | 17 (27) | 30 (71) | |
| 2 | 22 (21) | 16 (26) | 6 (14) | |
| 3 | 17 (16) | 14 (23) | 3 (7) | |
| >3 | 18 (17) | 15 (24) | 3 (7) | |
| Surgery | 0.821 | |||
| Yes | 68 (65) | 40 (65) | 28 (67) | |
| No | 36 (35) | 22 (35) | 14 (33) | |
| Chemotherapy | 0.161 | |||
| Yes | 102 (98.1) | 62 (100) | 40 (95.2) | |
| No | 2 (1.9) | — | 2 (4.8) | |
| Number of treatment lines | <0.001 | |||
| None | 2 (1.9) | — | 2 (4.8) | |
| 1 | 42 (40.4) | 8 (12.9) | 34 (81.0) | |
| 2 | 29 (27.9) | 24 (38.7) | 5 (11.9) | |
| 3 | 15 (14.4) | 15 (24.2) | — | |
| >3 | 16 (15.4) | 15 (24.2) | 1 (2.4) | |
| Follow-up (months) median (95% CI) | 43.0 (38.9–47.1) | 39.1 (30.7–47.6) | 44.5 (NA) | 0.070 |
| Vital status | 0.002 | |||
| Alive | 36 (34.6) | 14 (22.6) | 22 (52.4) | |
| Deceased | 68 (65.4) | 48 (77.4) | 20 (47.6) |
n, number of patients; IQR, interquartile range; 95% CI, 95% confidence interval; NA, not available.
a
P-values are calculated with the Chi-square test and Fisher’s Exact test for categorical variables, the Mann-Whitney U test for median age comparison between groups and the log-rank test for median follow-up comparison between groups.