Table 4.
Identification of thresholds using outcome cost‐based analysis and mathematical and risk score consistency.
| Outcome based ROC | Thresholds (calibrated to 1 y survival) | Physiological Consistency (centered on RVFAC relat.) | REVEAL lite (centered on 8/9 score) | |
|---|---|---|---|---|
| REVEAL lite | 0.74 (0.04) | ≥8 | 8.0 | ‐ |
| NT‐proBNP | 0.65 (0.04) | >1100 | 1031 | 1626 |
| RV function | ||||
| RVFAC (%) | 0.63 (0.04) | <19 | 19† | 18 |
| RVFWS (%) | 0.64 (0.04) | <10 | 12 | 10 |
| TAPSE/RVSP (mm/mmHg) | 0.59 (0.04) | <0.19 | 0.18 | 0.16 |
| RV base (end‐diastolic) | ||||
| RVEDD base (mm) | 0.62 (0.04) | >55 | 55 | 56 |
| RVEDDi (ht) (mm/m) | 0.63 (0.04) | >33 | 34 | 34 |
| RVEDD/LVID | 0.60 (0.04) | >1.5 | 1.5 | 1.5 |
| RV mid (end‐diastolic) | ||||
| RVEDD mid (mm) | 0.64 (0.04) | >50 | 49 | 51 |
| RVEDDi mid (ht) (mm/m) | 0.64 (0.04) | >30 | 30 | 31 |
| RVEDD mid/LVID | 0.62 (0.04) | >1.4 | 1.3 | 1.4 |
| RV areas (end‐diastolic) | ||||
| RVEDAi (bsa)(cm2) | 0.62 (0.04) | >21 | 21 | 21 |
| RVESAi (bsa) | 0.63 (0.04) | >17 | 17 | 18 |
| RVEDAr | 0.59 (0.04) | >2 | 2 | 2.0 |
| RVESAr | 0.62 (0.04) | >3 | 3 | 3.0 |
| RA size (maximal) | ||||
| RAA (cm2) | 0.58 (0.04) | >26 | 24 | 24 |
| RAAi (cm2/m2) | 0.60 (0.04) | >14 | 13 | 13 |
| RAVi (mL/m2) | 0.60 (0.04) | >50 | 47 | 43 |
| RAAr | 0.58 (0.04) | >1.9 | 1.8 | 1.7 |
| TR severity (grade) | 0.57 (0.04) | >2 | >2 | 2 |
| eRAP (mmHg) | 0.61 (0.04) | >8 | 8 | 15 |
| rRAP (RHC) | 0.60 (0.01) | >14 | >14 | 11 |
Abbreviations: PAWP, pulmonary capillary wedge pressure; RA, right atrial; RAP, RA pressure; RHC, right heart catheterization; ROC, receiver operating characteristic; RV, right ventricular; RVFAC, RV fractional area change; RVFWS, RV free wall longitudinal strain; TAPSE, tricuspid annular plane systolic excursion.