Figure 2.

A synthetic panel of polymers is layered onto nanoparticles and imbues pH-responsive surfaces. A) Extruded, anionic liposomal cores are adsorbed with the polycation poly-L-lysine, and polyanions 1-5 are layered, resulting in 5 distinct LbL NPs. Note copolymer and side chain fractions are calculated from the corresponding ¹H NMR spectra (Figure S2-5). B) Hydrodynamic diameters, polydispersity indices, and zeta potentials of the NPs display uniform nanoparticles. C) pH-accelerated charge reversal of NPs with hydrolytically cleavable side chains instills certain NPs with a pH-responsive surface. N = 3 technical replicates for both B and C.