Figure 5. .

Model-based susceptibility and information capacity changes under the psychedelic state. We used a model-based approach to assess the effects of external perturbations on brain dynamics. (A) We quantified the susceptibility measure, which estimates the responsiveness of the in silico whole-brain dynamics to external perturbations. LSD and psilocybin significantly decrease the susceptibility level compared with placebo. D values for LSD and psilocybin, respectively: d = 1.2522, d = 0.8336. (B) The information capacity measurement denotes the encoding capability of the whole-brain model. In other words, this appraisal captures how the simulated external perturbations are encoded in brain dynamics. Both psychedelic drugs significantly increase the information-encoding capacity. D values for LSD and psilocybin, respectively: d = 1.400, d = 2.5615. P values were assessed using the Wilcoxon rank sum test and corrected for multiple comparisons. * Indicates p < 0.05, ** indicates p < 0.01, and *** indicates p < 0.001.