Table 2.
Evaluation of heterogeneity and pleiotropy using different methods.
| Drug Target | Code | Outcomes | Code | Heterogeneity test Cochran’s Q P value |
Pleiotropy test | |
|---|---|---|---|---|
| MR-Egger intercept P value |
MR-PRESSO global test P value |
|||
| CACNA1D | ieu-b-38 | CAD | ebi-a-GCST005195 | 0.376 | 0.355 | 0.398 |
| CACNB2 | ieu-b-38 | CAD | ebi-a-GCST005195 | 0.097 | 0.402 | 0.133 |
| CACNB3 | ieu-b-38 | CAD | ebi-a-GCST005195 | 0.434 | 0.574 | 0.530 |
| CACNB2 | ukb-b-20175 | CAD | ebi-a-GCST005195 | 0.653 | 0.396 | 0.736 |
| CACNA1D | ebi-a-GCST90029011 | CAD | ebi-a-GCST005195 | 0.270 | 0.352 | 0.347 |
| CACNB2 | ebi-a-GCST90029011 | CAD | ebi-a-GCST005195 | 0.366 | 0.178 | 0.431 |
| CACNA1D | ebi-a-GCST90018972 | CAD | ebi-a-GCST005195 | 0.324 | 0.631 | 0.341 |
| CACNB2 | ebi-a-GCST90018972 | CAD | ebi-a-GCST005195 | 0.190 | 0.939 | 0.209 |
| CACNA1D | ieu-b-38 | Depression | ieu-b-102 | 0.656 | 0.338 | 0.686 |
| CACNB2 | ieu-b-38 | Depression | ieu-b-102 | 0.077 | 0.999 | 0.085 |
| CACNB3 | ieu-b-38 | Depression | ieu-b-102 | 0.714 | 0.404 | 0.759 |
| CACNB2 | ukb-b-20175 | Depression | ieu-b-102 | 0.204 | 0.357 | 0.225 |
| CACNA1D | ebi-a-GCST90029011 | Depression | ieu-b-102 | 0.609 | 0.423 | 0.675 |
| CACNB2 | ebi-a-GCST90029011 | Depression | ieu-b-102 | 0.070 | 0.999 | 0.072 |
| CACNA1D | ebi-a-GCST90018972 | Depression | ieu-b-102 | 0.324 | 0.631 | 0.341 |
| CACNB2 | ebi-a-GCST90018972 | Depression | ieu-b-102 | 0.190 | 0.939 | 0.209 |
CAD, coronary artery disease; MR-PRESSO, mendelian randomization pleiotropy residual sum and outlier.