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3D structure of PP2B. PP2B is associated with AD through the dephosphorylation of the tau protein at different phosphorylation sites, and it has also been observed that PP2B activity is either unchanged or decreased in the AD brain. Based on these speculations, PP2B might regulate tau phosphorylation, and a downregulation of PP2B might contribute to the abnormal hyperphosphorylation of tau [80,81].
