Table 1.
Protein Name | Amino Acid | Coding Gene | Disease | Ref | ||
---|---|---|---|---|---|---|
PP1 | 330 | PPP1CA | AD, Parkinson disease (PD), Huntington’s disease (HD), Schizophrenia |
[20,21,22,23] | ||
PP2A | Structural | 595 | Structural | PPP2R1A | AD, PD, Down syndrome, Frontotemporal dementia, Glioblastoma multiforme |
[24,25,26,27,28,29,30] |
Catalytic | 309–310 | Catalytic | PPP2CA | |||
Regulatory | 285–595 | Regulatory |
PPP2R2A
PPP2R2B PPP2R2C PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D |
|||
PP2B | 526 | PPP3CA | AD, PD, HD Schizophrenia |
[31,32,33] | ||
PP4 | Catalytic | 320 | Catalytic | PPP4C | AD | [34] |
Regulatory | 1700, 500 | Regulatory |
PPP4R2
PPP4R3 |
|||
PP5 | 525 | PPP5C | AD, PD, HD | [35,36] | ||
PP6 | Catalytic | 348 | Catalytic | PPP6C | AD, PD | [34,37] |
Regulatory | 343, 382 | Regulatory |
PPP6R1
PPP6R2 |
|||
PP7 | 653 | PPM1G | Retinitis Pigmentosa Retinoblastoma |
[38] |