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. 2024 May 15;12(5):1097. doi: 10.3390/biomedicines12051097

Table 1.

Comparison data of PP1–7 and their correlation with neurodegenerative diseases.

Protein Name Amino Acid Coding Gene Disease Ref
PP1 330 PPP1CA AD, Parkinson disease (PD), Huntington’s disease (HD),
Schizophrenia
[20,21,22,23]
PP2A Structural 595 Structural PPP2R1A AD, PD,
Down syndrome,
Frontotemporal dementia,
Glioblastoma multiforme
[24,25,26,27,28,29,30]
Catalytic 309–310 Catalytic PPP2CA
Regulatory 285–595 Regulatory PPP2R2A
PPP2R2B
PPP2R2C
PPP2R3A
PPP2R3B
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5D
PP2B 526 PPP3CA AD, PD, HD
Schizophrenia
[31,32,33]
PP4 Catalytic 320 Catalytic PPP4C AD [34]
Regulatory 1700, 500 Regulatory PPP4R2
PPP4R3
PP5 525 PPP5C AD, PD, HD [35,36]
PP6 Catalytic 348 Catalytic PPP6C AD, PD [34,37]
Regulatory 343, 382 Regulatory PPP6R1
PPP6R2
PP7 653 PPM1G Retinitis Pigmentosa
Retinoblastoma
[38]