Skip to main content
. 2024 May 18;14(5):599. doi: 10.3390/biom14050599

Figure 1.

Figure 1

Knockdown of the kynurenine pathway gene haao-1 delays paralysis in C. elegans models of polyglutamine and amyloid-beta proteotoxicity. (a) Schematic of the kynurenine pathway in C. elegans. Knockdown of haao-1 substantially delayed age-associated pathology in C. elegans expressing either (b) Aβ or (c) a 35-unit polyglutamine tract (Q35) in body wall muscle at 15 °C to a similar degree as previously reported knockdown of tdo-2 or kynu-1 [23]. Knockdown of haao-1 slightly delayed age-associated pathology in C. elegans expressing either (d) Aβ or (e) a Q35 in body wall muscle at 25 °C to a similar degree as previously reported knockdown of tdo-2 or kynu-1 [23]. Colored numbers indicate the percent change in mean age of paralysis vs. EV(RNAi). ** p < 0.01, *** p < 0.001 for log-rank test vs. EV(RNAi).