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. 2024 May 18;14(5):599. doi: 10.3390/biom14050599

Figure 3.

Figure 3

Knockdown of haao-1 does not prevent polyglutamine aggregation at 25 °C. (a) haao-1 knockdown did not affect the number of YFP-labeled muscle polyglutamine (Q35::YFP) protein aggregates at 25 °C, similar to our previous report for knockdown of kynu-1 and unlike knockdown of tdo-2, which reduced Q35::YFP aggregate number at all ages examined [23]. (b) haao-1 knockdown slightly reduced the volume of Q35::YFP protein aggregates at 25 °C, unlike our previous report for knockdown of tdo-2, which substantially reduced Q35::YFP aggregate volume both at all ages examined, or kynu-1, which did not reduce Q35::YFP volume [23]. (c) Representative images of Q35::YFP aggregation in each test group and age at 25 °C. * p < 0.05 for two-sided Welch’s t-test vs. age-matched EV(RNAi).