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. 2024 May 17;12(5):1118. doi: 10.3390/biomedicines12051118

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inhibition of NLRP3 inflammasome activation following anti-IL-17A-sST2 injection. (A) Representative images of immunohistochemistry analysis of TLR4 in liver tissues. (Magnification: 100×, 400×). Scale bar = 200 μm (100×) and 50 μm (400×). (B) Analysis of TLR4 in liver sections (n = 6). (C) The NLRP3 mRNA expression in the mice liver with indicated treatment (n = 4). (D,E) Western blot analysis of Caspase-1/Cleaved Caspase-1 in mice livers with indicated treatments (n = 4). (F) The mRNA expression of IL-1β in mice livers with indicated treatment (n = 4). The data in (B,C,E,F) represent means ± SDs. * p < 0.05, ** p < 0.01; p-values were determined by Student’s t-test.