Table 8.
Sex-specific differences of Trp and its eight metabolites levels in plasma from CTRL and AD patients; p-values in bold were considered significant.
| Analyte | Sex | Concentration (Mean ± SD) [ng/mL] | p-Value | |
|---|---|---|---|---|
| CTRL | AD | |||
| PA | F | 2.80 ± 0.74 | 5.11 ± 2.27 | 0.0002 |
| M | 3.70 ± 0.89 | 5.96 ± 2.04 | 0.0062 | |
| AA | F | 1.36 ± 0.30 | 1.66 ± 0.63 | 0.0790 |
| M | 1.53 ± 0.45 | 1.61 ± 0.44 | 0.6987 | |
| 3-OH AA | F | 7.38 ± 1.95 | 7.25 ± 2.87 | 0.8715 |
| M | 7.40 ± 2.20 | 7.85 ± 1.83 | 0.6301 | |
| KA | F | 14.42 ± 3.16 | 19.36 ± 7.81 | 0.0151 |
| M | 20.23 ± 6.76 | 17.87 ± 5.69 | 0.4198 | |
| 5-OH IAA | F | 13.80 ± 3.35 | 23.32 ± 19.23 | 0.0405 |
| M | 18.46 ± 6.11 | 22.86 ± 17.48 | 0.4818 | |
| Trp | F | 15,773.02 ± 2620.40 | 17,172.81 ± 4902.50 | 0.2825 |
| M | 15,378.28 ± 3649.57 | 13,703.87 ± 4202.85 | 0.3676 | |
| I3LA | F | 90.94 ± 16.76 | 114.75 ± 37.01 | 0.0154 |
| M | 149.24 ± 27.78 | 127.07 ± 29.65 | 0.1097 | |
| XA | F | 2.83 ± 1.97 | 2.34 ± 1.30 | 0.7063 |
| M | 3.07 ± 1.21 | 4.95 ± 2.09 | 0.0289 | |
| QA | F | 87.60 ± 32.72 | 127.79 ± 56.37 | 0.0112 |
| M | 87.98 ± 27.40 | 114.02 ± 45.39 | 0.1513 | |