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. 2005 Jun;73(6):3668–3676. doi: 10.1128/IAI.73.6.3668-3676.2005

FIG. 3.

FIG. 3.

Impaired granuloma formation in mice expressing high levels of sTNFR1 and enhanced granuloma formation in mice with low sTNFR1 levels after 4 weeks of BCG infection. Hematoxylin and eosin staining revealed well-differentiated granulomas in control mice (A), very few small granulomas in transgenic mice expressing high levels of sTNFR1 (B), and large well-differentiated granulomas in transgenic mice expressing low levels of sTNFR1 (C). Ziehl-Neelsen staining revealed the presence of few AFB in control mice (D), a higher number of AFB in transgenic mice expressing high levels of sTNFR1 (E), and few AFB in transgenic mice expressing low levels of sTNFR1 (F). The results are representative of the results of two independent experiments with five mice per group. (A to D and F) Magnification, ×344. (E) Magnification, ×400.