FIG. 6.

Altered serum levels of Th1-type cytokines in transgenic mice expressing high levels of sTNFR1. The levels of IFN-γ (A), IL-12p40 (B), and IL-18 (C) were determined by ELISA in serum from transgenic mice expressing high levels of sTNFR1 (high sTNFR1) and transgenic mice expressing low levels of sTNFR1 (low sTNFR1) and their control littermates before BCG infection (n = 3) and 2 weeks (n = 4), 4 weeks (n = 4 to 5), and 8 weeks (n = 4) after BCG infection. The data are expressed in picograms of protein per milliliter of serum and are means ± standard errors of the means. One asterisk indicates that the P value is <0.03, and two asterisks indicate that the P value is <0.003. The results are representative of the results of two independent experiments.