Table 5.
Tissue oxidative stress (IHC scores) stratified by clinical, surgical, and pathological variables.
| Pre-Res. UCP2 | Post-Res. UCP2 | Pre-Res. 4-HNE | Post-Res. 4-HNE | |
|---|---|---|---|---|
| Age > 60 years | ||||
| No | 134.2 (42.5) | 157.8 (39.7) | 85.9 (30.8) | 131.5 (47.3) |
| Yes | 132.4 (46.5) | 160.0 (45.8) | 101.6 (45.0) | 125 (45.4) |
| p-value * | 0.957 | 0.648 | 0.579 | 0.808 |
| Steatosis/fibrosis | ||||
| No | 131.8 (46.6) | 154.9 (41.9) | 88.6 (34.6) | 123.8 (47.3) |
| Yes | 137.7 (36.8) | 169.2 (43.4) | 108.1 (47.7) | 141.3 (40.7) |
| p-value * | 0.705 | 0.884 | 0.566 | 0.352 |
| Cholangiocarcinoma | ||||
| No | 131.0 (44.1) | 151.9 (41.2) | 90.5 (35.4) | 119.9 (45.3) |
| Yes | 143.1 (44.9) | 190.0 (33.8) | 106.7 (51.3) | 163.3 (30.8) |
| p-value * | 0.357 | 0.021 | 0.409 | 0.005 |
| Neoadjuvant CTX | ||||
| No | 135.0 (43.0) | 161.1 (40.6) | 97.9 (40.2) | 134.5 (44.1) |
| Yes | 123.6 (52.0) | 145.7 (52.2) | 68.9 (14.4) | 98.6 (43.2) |
| p-value * | 0.549 | 0.616 | 0.120 | 0.012 |
| Pringle maneuver | ||||
| No | 134.8 (41.1) | 159.2 (51.3) | 110.4 (49.2) | 146.9 (33.7) |
| Yes | 132.7 (45.8) | 158.5 (39.5) | 86.5 (31.7) | 121.1 (48.5) |
| p-value * | 0.843 | 0.354 | 0.305 | 0.297 |
| Intraop. transfusion | ||||
| No | 129.8 (44.2) | 162.3 (41.6) | 93.4 (39.7) | 131.0 (45.3) |
| Yes | 140.0 (44.3) | 151.3 (44.2) | 94.1 (38.3) | 123.4 (48.4) |
| p-value * | 0.444 | 0.351 | 0.973 | 0.437 |
| Major/minor | ||||
| Minor | 132.7 (46.2) | 160.7 (37.3) | 108.3 (33.5) | 123.2 (44.3) |
| Major | 133.6 (43.7) | 157.7 (44.9) | 86.7 (46.0) | 130.6 (47.2) |
| p-value * | 0.991 | 0.859 | 0.140 | 0.457 |
All data are given as means (standard deviation); * Mann–Whitney U test; pre-resection IHC scores are mean of bilobar biopsies. Abbreviations: 4-HNE = 4-hydroxynonenal; bx = biopsies; CTX = chemotherapy; IHC = immunohistochemistry; intraop. = intraoperative; UCP2 = uncoupling protein 2.