TABLE 3.
Individual pattern of differentially expressed macrophage genes in response to M. avium strain SE01
| Gene name (UniGene) | Designation | Fold regulationa |
|---|---|---|
| JAK binding protein | SSI-1 | 15.77 |
| Plasminogen activator, tissue | PLAT | 10.26 |
| Hairy (Drosophila) homolog | HRY | 8.51 |
| Platelet-derived growth factor beta polypeptide | PDGFB | 7.96 |
| Solute carrier family 1, glial high-affinity glutamate transport, membrane 2 | SLC1A2 | 7.33 |
| BCL2-like 1 | BCL2L1 | 7.18 |
| Signaling lymphocytic activation molecule | SLAM | 6.92 |
| Colony-stimulating factor 3 (granulocyte) | CSF3 | 6.69 |
| Colony-stimulating factor 2 (granulocyte-macrophage) | CSF2 | 6.66 |
| Interleukin 10 | IL10 | 5.95 |
| Dual-specificity phosphatase 8 | DUSP8 | 5.58 |
| Aldehyde dehydrogenase 5 | ALDH5 | 4.65 |
| Dual-specificity tyrosine-phosphorylation-regulated kinase 3 | DYRK3 | 3.56 |
| v-src avian sarcoma (Schmidt-Ruppin A-2) | SRC | 3.49 |
| Homo sapiens C2H2-type zinc finger protein mRNA, complete cds | 3.37 | |
| Thymopoietin | TMPO | 3.33 |
| CD83 antigen | CD83 | 3.31 |
| Growth arrest and DNA damage-inducible, alpha | GADD45A | 3.21 |
| Coagulation factor III (thromboplastin, tissue factor) | F3 | 3.20 |
| EST, moderately similar to POL2 human retrovirus-related POL polyprotein | 2.90 | |
| Dishevelled 3 (homologous to Drosophila dsh) | DVL3 | 2.78 |
| NCK adaptor protein 2 | NCK2 | 2.69 |
| Cytokine-inducible kinase | CNK | 2.69 |
| Acetyl LDL receptor; SREC | SREC | 2.69 |
| Mitogen-activated protein kinase-activated protein kinase 2 | MAPKAPK2 | 2.67 |
| Prostaglandin I2 (prostacyclin) receptor (IP) | PTGIR | 2.60 |
| Dual-specificity phosphatase 1 | DUSP1 | 2.60 |
| Glycophorin C (Gerbich blood group) | GYPC | 2.60 |
| Creatine kinase, brain | CKB | 2.53 |
| Glutaredoxin (thioltransferase) | GLRX | 2.38 |
| X-box binding protein 1 | XBP1 | 2.36 |
| Prostaglandin E receptor 4 (subtype EP4) | PTGER4 | 2.31 |
| Signal transducer and activator of transcription 5A | STAT5A | 2.28 |
| Pleiomorphic adenoma gene-like 2 | PLAGL2 | 2.24 |
| CCAAT/enhancer binding protein (C/EBP), delta | CEBPD | 2.20 |
| Guanylate binding protein 2, interferon inducible | GBP2 | 2.18 |
| BTG family, member 3 | BTG3 | 2.13 |
| ras homolog gene family, member G (rho G) | ARHG | 2.09 |
| KIAA0759 protein | KIAA0759 | −2.07 |
| cAMP-responsive element modulator | CREM | −2.09 |
| Diacylglycerol kinase, zeta (104kD) | DGKZ | −2.11 |
| Myeloid cell nuclear differentiation antigen | MNDA | −2.12 |
| Homo sapiens cDNA: FLJ21449 fis, clone COL04483, highly similar to AF010235 H. sapiens mRNA from chromosome 5q31-33 region | −2.15 | |
| Putative human HLA class II associated protein I | PHAP1 | −2.17 |
| Interferon gamma receptor 1 | IFNGR1 | −2.19 |
| Src-like-adapter | SLA | −2.19 |
| RAS p21 protein activator (GTPase activating protein) 1 | RASA1 | −2.20 |
| Homo sapiens mRNA; cDNA (from clone DKFZp564N1272); complete cds | −2.22 | |
| DKFZP566O1646 protein | −2.24 | |
| Proliferating cell nuclear antigen | PCNA | −2.26 |
| KIAA0229 protein | KIAA0229 | −2.28 |
| Nucleoporin 214kD (CAIN) | NUP214 | −2.30 |
| Human clone 23801 mRNA sequence | −2.30 | |
| MKP-1 like protein tyrosine phosphatase | MKP-L | −2.31 |
| Speckle-type POZ protein | SPOP | −2.33 |
a
Positive values indicate fold induction, and negative values indicate fold suppression.