Figure 1. We built a cardiomyopathy stem cell biobank for 300 donors.

A. We created a biobank of stem cells from 300 donors exhibiting either HCM, DCM, LVNC, or serving as controls. iPS cells were profiled by whole genome sequencing and a subset differentiated into cardiomyocytes for additional profiling via RNA-seq, drug treatment, and microscopy-based contractility assaying. B. Plotted are the datasets which passed quality control filtering. Numbers indicate number of donors for each dataset type. The actual number of datasets is higher due to replicates. Abbreviations: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), left ventricular noncompaction (LVNC), induced pluripotent stem cells (iPS cells), whole genome sequencing (WGS), RNA sequencing (RNA-seq), dimethyl sulfoxide (DMSO), mavacamten (myk), omecamtiv mecarbil (omec).