Figure 3. Prospective time course longitudinal analysis of saliva samples for Hst-5 from two subjects with moderate COVID-19.

Changes in Hst-5 and cytokine concentrations in two longitudinally sampled subjects prior to and during the acute and post-acute phases of COVID-19 disease. Timeline of sampling during COVID-19 infection up to 49 and 85 days post-COVID-19 infection for subjects 1 and 2 (a and c, respectively). Measurement of Hst-5 concentrations and fungal culturing of samples from the two subjects prior to and during the acute and post-acute phases of COVID-19 disease. Line graphs in bottom rows depict similar trends for Hst-5 and Th17 associated cytokine levels for subjects 1 and 2 (b and d, respectively). Upon culturing, C. albicans was recovered from the initial 6 samples from subject 2 (c, d).