FIG. 1.
Murine Lyme arthritis is unaffected by CD18 deficiency. (Left) The graph depicts the variation in average ankle width (a measure of arthritis edema) over the course of the experiment in uninfected WT (open circles; n = 2 mice) or CD18 hypomorph (open squares; n = 2 mice) and infected WT (filled circles; n = 8 mice) and CD18 hypomorph (filled squares; n = 7 mice) mice, with error bars corresponding to standard deviations of the means. Both ankles were measured for each mouse. Results correspond to one experiment, which is representative of five independent experiments. No significant differences in day of onset or ankle width were observed between the two experimental groups. (Right) Lyme arthritis pathology in WT and CD18 hypomorph mice at 3 weeks postinfection, determined by histopathology score (see Materials and Methods). Each symbol in the graph represents the histopathology score of one individual ankle, with two ankles per mouse included in the analysis, and the average of each experimental group is depicted as a horizontal line. Data correspond to one experiment, representative of three independent experiments. No significant differences were observed between groups (the average ± standard deviation was 1.6 ± 1.2 for WT and 2.25 ± 0.88 for CD18 hypomorph mice; P = 0.22, not significant by an unpaired t test). CD18hypo, CD18 hypomorph mice.