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. 2024 May 23;55:67. doi: 10.1186/s13567-024-01316-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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UNA suppresses the phosphatase activity of PTPN1. A PTPN1 expression in Marc-145 cells treated with DMSO or UNA. The histogram on the right is a statistical analysis of the Western blot data. B Protein tyrosine phosphatase (PTP) activity in Marc-145 cells treated with DMSO or UNA. C Expression and purification of chloPTPN1. i Recombinant protein precipitates before (Lane 2) and after (Lane 3) purification were subjected to SDS‒PAGE. Lane 1, Rosetta-pET-28a-chloPTPN1 with IPTG induction. Lane 4, Rosetta-pET-28a with IPTG induction. ii and iii The purified protein was analysed by Western blotting. D Phosphatase activity of chloPTPN1 after incubation with UNA. The results are from one of three independent experiments. The data are presented as the means ± SDs. The asterisks in the figures indicate significant differences (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant).