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. 2024 May 23;55:67. doi: 10.1186/s13567-024-01316-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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PTPN1 attenuates IFN-β production induced by RLR-mediated signalling. HEK293T cells were transfected with the indicated plasmids, chloPTPN1-myc, and the IFN-β luciferase reporter plasmids for 24 h. The cell lysates were harvested for immunoblotting with the indicated antibodies and for luciferase assays to detect the effect of PTPN1 on the activation of the IFN-β promoter induced by RIG-I A, MDA5 B, MAVS C, TBK1 D, IKKε E, and IRF3 F. The results are from one of three independent experiments. The data are presented as the means ± SDs. The asterisks in the figures indicate significant differences (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant).