Figure 3. Subnetworks of age-related rsFC differences.

Figures on the left in both panels display the dense subnetworks extracted using the data-driven subnetwork detection method, highlighted with red boxes. Each matrix element is −log₁₀(p-values) (top left) and corresponding t-statistic (bottom left) obtained from association analysis between each rsFC edge and age. The top right figures in both panels represent the mapping of the large sensorimotor-and-attention-related subnetwork onto Yeo’s 7 resting-state functional networks. The red boxed regions are the hubs consisting of hypergranular insula and dorsal granular insula that have decreased rsFC with the all other sensorimotor-and-attention-related regions in the subnetwork. The bottom right figures in both panels present the systematic differences between the t-statistics within and beyond the extracted subnetworks.