FIG. 7.

Ad-elafin treatment results in the reduction of neutrophil clusters after intratracheal administration of S. aureus in mice. The histological appearance (magnification, ×400) of representative 3-μm lung sections (fixed in formalin, embedded in paraffin, and stained with hematoxylin and eosin) is shown. (b and c) Ad-elafin-S. aureus treatment reduced the numbers of neutrophil clusters (occasional “isolated” neutrophils were observed, see arrows) (c) compared to Ad-LacZ-S. aureus treatment, where multiple clusters were present (b, arrows). (a) None were seen in PBS-PBS-treated animals. Corresponding neutrophil numbers from each section are shown in the relevant bar graph.