Figure 4. Associations of psychopathology and cognitive function with individuals carrying known pathogenic recurrent CNVs associated with neurodevelopmental disorders.
(A) Association of overall and dimensional psychopathology with neurodevelopmental CNVs. Individuals with neurodevelopmental CNVs had significantly elevated psychopathology in the social domain at FDR-corrected p<0.05. (B) Association of global and dimensional cognitive function with neurodevelopmental CNVs. Individuals with neurodevelopmental CNVs had lower cognitive performance across domains including fluid intelligence, attention, working memory, flexible thinking, reading ability and processing speed (pFDR<0.05). Points in the dot plots indicate the value of a given predictor variable’s standardized effect size and error bars indicate 95%CIs for models of cognition and psychopathology.