Fig. 1. Overview of the Sherlock-Lung cohort of lung cancers in never smokers.

a, Geographical distribution of the 871 patients across four continents and 28 geographic locations. b, Clinical characterization based on histology, genetic ancestry, geographical region, biological sex, and passive smoking status. c, Prevalence of mutations, percentage of genome altered, and structural variants across geographic locations and stratified based on histology. Left panel, dots represent median values for the three genomic alterations individually per country and histology. Right panel, dots represent individual tumors, colors different histology types, and horizontal purple lines median values across all histologies. d, Landscape of mutational signatures across histologies and somatic variant classes, including single base substitutions (SBS), doublet base substitutions (DBS), small insertions and deletions (ID), copy number alterations (CN), and structural variants (SV). The size and color of the dots represent the percentage of mutations contributed by the signature in all samples sharing the same histology (top panel) or the percentage of samples of a histological type where a particular signature is active (bottom panel). AS: East Asian geographical regions, EAS: East Asian genetic ancestry super-sample, EUR: European genetic ancestry super-sample, LUAD: lung adenocarcinomas, LUSC: lung squamous cell carcinomas, NA/EU: North America and Europe geographical regions.