Extended Data Figure 5. Comparison of PO distribution for real V1-to-V2 connection data with simulated data following a perfect like-to-like connectivity rule.

(A) Distribution of POs of V1 cells predicted by a perfect like-to-like connectivity rule (black curve) modeled by weighted summing over three Gaussian functions (gray curves) centered at 45°, 67.5°, and 90°, respectively, corresponding to three orientation columns in V2 involved by the real V2 injection site in case MK373-CTB647. (B) Simulated PO distribution (after binning) of V1 cells under a perfect like-to-like connectivity rule (black bars (see Methods). The simulated distribution differs significantly (p<0.05, Chi square comparison) from the distribution of POs obtained from the real V1 data (colored bars). Gray bars: Distribution of POs at the real V2 injection site.