FIG. 2.
CBL and maternal PBMC ELISPOT assay IFN-γ responses to malaria blood-stage antigens (Ag). Only the geometric means and ranges of frequencies of IFN-γ-secreting cells per 106 CBL or maternal PBMC for individuals responding to MSP-1, PfP0 peptides, and recombinant EBA-175 are shown. The maximum responses to MSP-1 and PfP0 peptides are shown and were used to calculate the geometric means. The proportion of newborns with IFN-γ-secreting cells was lower than that for their mothers (P < 0.05 to 0.01). A total of 169 CBL and 116 maternal PBMC donors were examined in response to MSP-1 and PfP0 and 132 CBL and 114 PBMC in response to EBA-175. The horizontal bars indicate the geometric means.