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. 2005 Jun;73(6):3301–3306. doi: 10.1128/IAI.73.6.3301-3306.2005

FIG. 2.

FIG. 2.

Serum levels of TNF-α in mice inoculated intradermally with M. tuberculosis recombinant antigens. C3H/HeJ mice were infected i.v. with 105 CFU of M. tuberculosis H37Rv, and at day 14 postinfection they were inoculated intradermally (at the base of the tail) with various concentrations of CFP-10, with saline, or with LPS. Sera were obtained from blood drawn 2 h later from the retroorbital plexus and assayed for TNF-α by ELISA (A). (B) Serum TNF-α levels determined in both noninfected C3H/HeJ mice and M. tuberculosis-infected C57BL/6 mice skin tested 2 h previously with saline or with 50 μg of either CFP-10 or Mtb 72F antigen. The bars indicate the results obtained for three animals. The data are from one representative experiment of three experiments in which basically the same results were obtained.