FIG. 5.

H&E-stained lung section of an M. tuberculosis-infected guinea pig skin tested with CFP-10. The lung was harvested during the autopsy of an M. tuberculosis-infected guinea and skin tested with 10 μg of CFP-10. The guinea pig died ∼10 h after the skin test. Lung sections were formalin fixed and H&E stained. Note the intense polycythemia in the lung tissue and hemorrhagic patches (arrows) surrounding a typical tuberculous granuloma (star). Identical pathology was observed in lung sections of six other infected animals that died after intradermal inoculation of CFP-10.