Figure 2.

Effect of pteF and pteR deletion on avermectin and filipin production. (a) Filipin III titer of mutant strain savΔpteF and savΔpteR under different fermentation times. (b) Avermectin B_1a titer of mutant strain savΔpteF and savΔpteR under different fermentation times. Data were obtained from three independent replicates. Student’s t-test (two-tail) was used to demonstrate the statistical significance, with * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 and “ns” meaning not significant.