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Effect of B355252 on NLRP3 in LPS-injected animals. NLRP3-positive cells are labeled in green, and nuclei are stained in red with propidium iodide. Following 24 h of LPS injection, there was an increase in the NLRP3 immunoreactivity in the Cpu and hilus. Conversely, B355252 reduced the NLRP3 fluorescent intensity in the cortex, Cpu, hilus, and CA3 regions. Data in the bar graphs are presented as mean +/− SD. * for p < 0.05 vs. NC; # for p < 0.05 vs. LPS24h.
