Table 2.
Differences in MRI markers of SVD between patients with LIS and dICH.
| MRI markers of SVD | LIS (n = 834) | dICH (n = 405) | p Value |
|---|---|---|---|
| Lacunes | |||
| Any lacune, n (%) | 346 (41.5) | 143 (35.3) | 0.037 |
| Lacune count if lacunes present, median (IQR) | 2 (1–3) | 1 (1–2) | <0.001 |
| Lobar lacune, n (%) | 199 (23.9) | 81 (20.0) | 0.127 |
| Non-lobar lacune, n (%) | 268 (32.1) | 100 (24.7) | 0.007 |
| WMH | |||
| Total WMH score, median (IQR) | 2 (1–4) | 3 (1–4) | 0.146 |
| Periventricular WMH score, median (IQR) | 1 (1–2) | 1 (1–2) | 0.141 |
| Periventricular WMH score ⩾2, n (%) | 354 (42.4) | 187 (46.2) | 0.215 |
| Deep WMH score, median (IQR) | 1 (0–2) | 1 (0–2) | 0.227 |
| Deep WMH score ⩾2, n (%) | 276 (33.1) | 155 (38.3) | 0.073 |
| WMH volume, %ICV, median (IQR) a | 0.5 (0.3–1.2) | 0.5 (0.2–1.2) | 0.248 |
| WMH patterns, n (%) | |||
| Multiple subcortical spots | 136 (16.3) | 64 (15.8) | 0.821 |
| Anterior subcortical patches | 95 (11.4) | 67 (16.5) | 0.012 |
| Large posterior subcortical patches | 118 (14.1) | 79 (19.5) | 0.016 |
| Peri-basal ganglia pattern | 75 (9.0) | 36 (8.9) | 0.952 |
| PVS | |||
| BG-PVS score, median (IQR) | 2 (1–2) | 2 (1–2) | 0.385 |
| Moderate-to-severe BG-PVS, n (%) | 501 (60.1) | 236 (58.3) | 0.545 |
| CSO-PVS score, median (IQR) | 2 (2–3) | 2 (2–3) | 1.000 |
| Moderate-to-severe CSO-PVS, n (%) | 717 (86.0) | 350 (86.4) | 0.830 |
| CMB b | |||
| Any CMB, n (%) | 93/243 (38.3) | 93/148 (62.8) | <0.001 |
| CMB count if CMB present, median (IQR) | 4 (2–8) | 3 (2–7) | 0.812 |
| Strictly lobar CMB, n (%) | 12/243 (4.9) | 6/148 (4.1) | 0.686 |
| Deep/mixed CMB, n (%) | 81/243 (33.3) | 87/148 (58.8) | <0.001 |
a
Available in 489 patients.
b
Available in 391 patients.
BG, basal ganglia; CSO, centrum semiovale; CMB, cerebral microbleeds; dICH, deep intracerebral hemorrhage; ICV, intracranial volume; IQR, interquartile range; LIS, lacunar ischemic stroke; MRI, magnetic resonance imaging; PVS, perivascular spaces; SVD, small vessel disease; WMH, white matter hyperintensities.