Figure 5.

Raising Nrf2 produces many heath-promoting effects. While Nrf2 is most known for producing large increases in antioxidant enzymes, Nrf2 also raises other health-promoting effects, as shown in the lower right. It has the ability to lower NF-kappa and inflammation, to improve mitochondrial function. It acts to get rid of dysfunctional organelles and of destructive protein aggregates (via autophagy). It detoxifies the body of carbon-containing toxicants and toxic metals. These various effects help down-regulate the NO/ONOO(-) cycle. Findings are described in the text that strongly suggest that raising Nrf2 may help in the treatment of ASDs and may even ameliorate ASD cases by acting during pregnancy. Various nutrients that raise Nrf2 are discussed in [244].