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. 2024 Jan 29;14(5):2137–2152. doi: 10.1016/j.apsb.2024.01.014

Figure 3.

Figure 3

ERβ agonism improves adipose remodeling in subcutaneous fat. (A) Aged sWAT mass after the treatment. (B) H&E staining of sWAT. Scale bar, 200 μm. (C) Quantification of adipocyte size in sWAT. (D) qPCR analysis of adipogenic and lipogenic genes in sWAT; (E) The expression of brown adipocyte makers in sWAT. ∗P < 0.05, ∗∗P < 0.01, n.s., not significant, n = 5. (F) Oil Red O and BODIPY staining of 3T3-L1 adipocytes for neutral lipids. Scale bar, 50 μm. (G) qPCR analysis of adipogenic, lipogenic, and browning genes in differentiated 3T3-L1 adipocytes treated with agonist conjugates and parent compounds. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, n = 4 for all groups. All values are presented as the mean ± SEM.