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Synthesis of ERβ agonist conjugates. Synthetic ERβ agonist GTx878 conjugated with tranexamic acid (TXA) to generate a monoester derivative, VB-165 (Top). Natural ERβ agonist genistein conjugated with TXA to yield a monoester derivative, JW-127 (Middle). Genistein conjugated with α-lipoic acid (ALA) to generate JW-191 (Bottom).
