Figure 6.

Lung transplant T cell composition after MSC^IL-10 treatment 3 days after transplantation. T cells and their subtypes in lung transplants 3 days after transplantation were quantified by flow cytometry. Lung (A) CD3⁺, (B) CD4⁺ and (C) CD8⁺ T cells were increased in transplants that had received 40 × 10⁶ MSCs^IL-10. T cell subtype analysis showed that treatment with 40 × 10⁶ MSCs^IL-10 significantly increased (D) CD45RO⁻CD62L⁺ central memory CD4⁺ T cells and (E) CD45RO⁺CD62L⁺ naïve CD8⁺ T cells and IFNγ⁺ cytotoxic CD8⁺ T cells. Data mean ± standard deviation and analyzed by 1-way ANOVA with Dunnett’s correction comparing treatment groups to the control group. * p < 0.05, ** p < 0.01. IFN, interferon; MSC, mesenchymal stromal cell; Treg, regulatory T cell.