Table 5.
Associations between NPI sub-domains scores (numerical variables) and CT of cortical ROIs and V of subcortical ROIs.
| NPSs | AD (n=41) | non-AD (n=16) | MCI (n=27) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ROIs | b | p-value | ROIs | b | p-value | ROIs | b | p-value | |
| Delusions | Pars orbitalis - R Entorhinal - L |
-0.332 -0.380 |
0.039 0.029 |
Temporal pole - R | 0.602 | 0.049 | Pars triangularis – L Rostral anterior cingulate – L Hippocampus – R Hippocampus - L |
0.462 0.514 0.624 0.482 |
0.036 0.033 0.012 0.041 |
| Depression | - | - | - | - | - | - | Paracentral – L Posterior cingulate – L |
-0.386 0.384 |
0.039 0.049 |
| Eating abnormalities | Pars opercularis - R | -0.347 | 0.044 | Insula - L | -0.639 | 0.022 | Caudal middle frontal - R Entorhinal - R Para-hippocampal - R Temporal pole - R Temporal pole - L Fusiform - R Amygdala – R Amygdala - L |
-0.532 -0.499 -0.508 -0.668 -0.476 -0.468 -0.626 -0.443 |
0.025 0.018 0.018 0.001 0.022 0.037 0.003 0.048 |
| Apathy | Pars triangularis - R Precentral - L |
-0.360 -0.356 |
0.037 0.044 |
Pars opercularis - R | -0.629 | 0.041 | Paracentral-L Accumbens area - L |
-0.451 0.448 |
0.034 0.037 |
| Euphoria | - | - | - | - | - | - | Entorhinal - R Para-hippocampal - R Caudal middle frontal - R Rostral anterior cingulate - R Temporal pole – R Parahippocampal - R Temporal pole - L Fusiform - R Amygdala - R Amygdala – L Hippocampus - R |
-0.525 -0.521 -0.580 -0.415 -0.673 -0.521 -0.480 -0.539 -0.714 -0.540 -0.493 |
0.01 0.012 0.012 0.047 0.000 0.012 0.018 0.012 0.000 0.011 0.043 |
| Night-time behaviour disturbances | Paracentral - R | -0.363 | 0.039 | Frontal pole – R Lateral orbito-frontal - R |
-0.610 -0.629 |
0.011 0.029 |
Amygdala-R | -0.507 | 0.023 |
| Agitation | Temporal pole - R Caudal middle frontal - R Pars opercularis - R Pars triangularis - R |
-0.386 -0.344 -0.440 -0.439 |
0.029 0.04 0.008 0.01 |
Lateral orbito-frontal -R | -0.660 | 0.04 | - | - | - |
| Aberrant motor behaviour | Entorhinal-L | -0.362 | 0.038 | Temporal pole - R | 0.479 | 0.039 | Rostral middle frontal – R Rostral middle frontal – L Rostral anterior cingulate – R Superior frontal – R Isthmus cingulate – L Accumbens area - L |
-0.533 -0.466 -0.503 -0.457 0.502 -0.436 |
0.026 0.045 0.017 0.044 0.029 0.048 |
| Anxiety | - | - | - | - | - | - | Isthmus cingulate – L Caudate – R |
-0.449 -0.436 |
0.024 0.021 |
| Hallucinations | Entorhinal - L | -0.348 | 0.043 | Temporal pole – R Amygdala - R |
0.549 0.521 |
0.032 0.032 |
- | - | - |
| Disinhibition | Insula - L | 0.478 | 0.005 | - | - | - | Entorhinal - R Temporal pole - R Fusiform - R Amygdala-R |
-0.481 -0.502 -0.535 -0.477 |
0.027 0.019 0.018 0.037 |
| Irritability | – | – | – | Medial orbito-frontal - R | -0.634 | 0.025 | Rostral middle frontal - R Rostral middle frontal - L Pars opercularis - R Pars triangularis - L |
0.575 0.526 0.500 0.466 |
0.011 0.016 0.014 0.025 |
Coefficients and p-values of the multivariate linear regression adjusted for age, disease duration and MMSE are shown.
To make the table easier to read, only the results that are statistically significant have been included. The full results are provided in Supplementary Table 6 . AD, Alzheimer’s disease; MCI, mild cognitive impairment; NPS, neuropsychiatric symptom; R, right; L, left.