Table 4.

Multivariate Cox regression analysis of bone fracture on incident myocardial infarction in 2009–2015 merging the blood biomarker data

	2009–2015
	HR	95%CI	P value
Model 1	1.88	1.10–3.24	0.022
Model 2	1.94	1.12–3.33	0.017
Model 3	1.78	1.03–3.06	0.038
Model 4	1.80	1.05–3.10	0.034

Model 1: adjusted for age, gender, BMI, hypertension, diabetes, smoking, alcohol consumption, TC, LDL-C (TC and LDL-C were included as continuous variables)

Model 2: Model 1 + eGFR (as continuous variables)

Model 3: adjusted for age, gender, BMI, hypertension, diabetes, smoking, alcohol consumption, TC, LDL-C (TC and LDL-C were included as categorical variables: for TC, < 5.2 and ≥ 5.2mmol/L, for LDL-C, < 3.4 and ≥ 3.4 mmol/L)

Model 4: Model 3 + eGFR (as categorical variables: <90 and ≥ 90 ml/min/1.73m²)

TC, total cholesterol; LDL-C, low density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate