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. 2005 May;187(10):3421–3430. doi: 10.1128/JB.187.10.3421-3430.2005

FIG. 1.

FIG. 1.

(A) Structural organization of N. meningitidis crgA and mdaB genes (not to scale). Genes are indicated by their designations. The open box represents the 138-bp Rep2/CREN repetitive DNA element. crgA codes for a 299-amino-acid protein belonging to the LysR family (NMB1856), and mdaB codes for an NADPH-quinone oxidoreductase (192 amino acids). The arrows indicate the direction of transcription. Probe1 represents the DNA segment used as a probe in S1 nuclease protection experiments; the asterisk indicates the radioactively labeled end. (B) Nucleotide sequence of the mdaB-crgA intergenic sequence. The shaded arrows indicate directions of translation. The bent arrows indicate transcriptional start sites. Underlined boldface letters indicate −10 and −35 promoter consensus sequences. The Rep2/CREN DNA sequence is enclosed in a box. The dotted lines indicate the CrgA binding site according to Deghmane et al. (3). SD, Shine-Dalgarno sequence.