Table 1.
Previous reports of HL C57BL/6J mice treated with CY: the 20 most up- and downregulated genes among the 52,142 genes examined.
| Upregulated genes: | |||
| Gene Symbol | Acc# | Z score | Gene name |
| Hmox1 | NM_010442 | 9.075 | Haem oxygenase 1 |
| Hamp | NM_032541 | 8.900 | Hepcidin antimicrobial peptide |
| Mt2 | NM_008630 | 8.579 | Metallothionein 2 |
| Serpina3n | NM_009252 | 8.301 | Serine (or cysteine) peptidase inhibitor clade A, member 3N |
| Dmkn | NM_001166173 | 7.662 | Dermokine, transcript variant 3 |
| Cd207 | NM_144943 | 7.595 | CD207 antigen |
| Dkk3 | NM_015814 | 7.498 | Dickkopf WNT signalling pathway inhibitor 3, transcript variant 2 |
| Mlana | XM_011247400 | 7.345 | Melan-A |
| Sfrp5 | NM_018780 | 7.028 | Secreted frizzled-related sequence protein 5 |
| Pip5k1a | AK167816 | 6.856 | Phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha |
| Clec1b | NM_019985 | 6.784 | C-type lectin domain family 1, member b, transcript variant 1 |
| Anxa8 | NM_013473 | 6.760 | Annexin A8, transcript variant 1 |
| Fam32a | NM_026455 | 6.494 | Family with sequence similarity 32, member A |
| Gp9 | NM_018762 | 6.430 | Glycoprotein 9 (platelet) |
| Lgals3 | NM_001145953 | 6.298 | Lectin, galactose binding, soluble 3, transcript variant 1 |
| Fam183b | NM_029283 | 6.237 | Family with sequence similarity 183, member B transcript variant 1 |
| Clec4d | NM_010819 | 6.155 | C-type lectin domain family 4, member d, transcript variant 1 |
| Cntf | NM_170786 | 6.133 | Ciliary neurotrophic factor |
| Ppbp | NM_023785 | 6.065 | Pro-platelet basic protein |
| Gata2 | NM_008182 | 5.986 | Glutathione S-transferase, alpha 2 |
| Downregulated genes: | |||
| Gene Symbol | Acc# | Z score | Gene name |
| Cx3cr1 | NM_009987 | −6.630 | Chemokine (C-X3-C motif) receptor 1 |
| Nckap5 | NM_172484 | −5.346 | NCK-associated protein 5, transcript variant 2 |
| Aplnr | NM_011784 | −5.227 | Apelin receptor |
| Apln | NM_013912 | −5.118 | Apelin |
| Itga9 | NM_133721 | −4.791 | Integrin alpha 9, transcript variant 1 |
| Tfrc | NM_011638 | −4.554 | Transferrin receptor, transcript variant 1 |
| Ppargc1b | NM_133249 | −4.504 | Peroxisome proliferative activated receptor, gamma, coactivator 1 beta, transcript variant 1 |
| Akap7 | XM_006512789 | −4.497 | A kinase (PRKA) anchor protein 7 |
| Cops8 | NM_133805 | −4.479 | COP9 signalosome subunit 8 |
| Plekhh1 | NM_181073 | −4.462 | Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 |
| Galnt17 | NM_145218 | −4.418 | Polypeptide N-acetylgalactosaminyltransferase 17 |
| Large1 | NM_010687 | −4.360 | LARGE xylosyl- and glucuronyltransferase 1, transcript variant 2 |
| Klhdc8a | NM_144810 | −4.358 | Kelch domain containing 8A |
| Kcne1 | NM_008424 | −4.307 | Potassium voltage-gated channel, lsk-related subfamily, member 1 |
| Nrn1 | NM_001374754 | −4.275 | Neuritin 1, transcript variant 2 |
| Klra8 | NM_010650 | −4.228 | Killer cell lectin-like receptor, subfamily A, member 8, transcript variant 2 |
| Ccl21a | NM_011124 | −4.226 | Chemokine (C-C motif) ligand 21A (serine) |
| Dbp | NM_016974 | −4.233 | D site albumin promoter binding protein |
| Fhl2 | NM_010212 | −4.201 | Four and a half LIM domains 2, transcript variant 1 |
| Tuba4a | NM_009447 | −4.169 | Tubulin, alpha 4A, transcript variant 1 |