Table 2.
Summary of studies included in the systematic review.
| Study | MSC Type | Defect Inclusion Criteria | Group Characteristics | Number of Patients | Number of Defects | Primary Outcomes | |||
|---|---|---|---|---|---|---|---|---|---|
| Test | Control | Test | Control | Test | Control | ||||
| Apatzidou et al., 2021 [55] | Autologous alveolar bone marrow mesenchymal stem cells (ABMMSCSs) | Infrabony defect (5 1-wall defects in the control groups; 3 2-wall defects in the test group and 3 in the control groups; 6 3-wall defects in the test group and 10 in the control groups) | ABMMSCs + autologous fibrin/platelet lysate (aFPL) + collagen scaffold + MIST | Group B: autologous fibrin/platelet lysate (aFPL) + collagen scaffold + MIST Group C: MIST | 9 | 10 + 8 | 9 | Group B: 10 Group C: 8 | CAL; PPD; GR; BDD; BC-BD |
| Sanchez et al., 2020 [57] | Autologous periodontal ligament-derived mesenchymal stem cells (PDLSCs) | Infrabony defect (3 1-wall defects in the test group; 7 2-wall defects in the test group and 10 in the control group) | PDLSCs + bone xenograft | Bone xenograft | 10 | 10 | 10 | 10 | CAL; PPD; GR |
| Abdal-Wahab et al., 2020 [54] | Autologous gingival-associated mesenchymal stem cells (GMSCs) | Infrabony defect (7 2-wall defects in the test group and 6 in the control group; 3 3-wall defects in the test group and 4 in the control group) | GMSC + (beta-tricalcium phosphate (β-TCP) + collagen membrane | Beta-tricalcium phosphate (β-TCP) + collagen membrane | 10 | 10 | 10 | 10 | CAL; PPD |
| Hernández-Monjaraz et al., 2020 [52] | Autologous dental pulp stem cells (DPSCs) | Infrabony defects | DPSCs + collagen scaffold | Collagen scaffold | 11 | 10 | 11 | 10 | PPD |
| Ferrarotti et al., 2018 [56] | Autologous dental pulp stem cells (DPSCs) | Infrabony defect (7 1-wall defects in the test group and 5 in the control group; 4 2-wall defects in the test group and 5 in the control group; 4 3-wall defects in the test group and 4 in the control group) | DPSCs + MIST + collagen sponge | MIST + collagen sponge | 15 | 14 | 15 | 14 | CAL; PPD; GR; BC-BD |
| Shalini and Vandana 2018 [53] | Autologous periodontal ligament-derived mesenchymal stem cells (PDLSCs) | Infrabony defects | OFD + PDLSCs | OFD | 14 | 14 | 14 | 14 | CAL, PPD |
| Chen et al., 2016 [19] | Autologous periodontal ligament-derived mesenchymal stem cells (PDLSCs) | Infrabony defect (Defect characteristics not mentioned) | PDLSCs + GTR + Bio-oss | GTR + Bio-oss | 20 | 21 | CAL; PPD; GR; BDD | ||
Legend: CAL: clinical attachment level; PPD: probing pocket depth; GR: gingival recession; BDD: linear distance from cementoenamel junction to bottom of defect; BC-BD: linear distance from bone crest to bottom of defect; MIST: minimally invasive surgical technique; MSC: mesenchymal stem cell; GTR: guided tissue regeneration; OFD: open flap debridement.