Table 1.
PharmGKB clinical annotations about ABCB1 genetic variants and antidepressants.
| PharmGKB ID | Level | Variant | Gene | Drugs | Phenotype Categories |
|---|---|---|---|---|---|
| 1183619292 | 3 | rs10248420 | ABCB1 | amitriptyline; citalopram; paroxetine; venlafaxine | Efficacy |
| 1183619303 | 3 | rs10280101 | ABCB1 | amitriptyline; citalopram; paroxetine; venlafaxine | Efficacy |
| 655384846 | 3 | rs1045642 | ABCB1 | Nortriptyline | Toxicity |
| 1447943597 | 3 | rs1045642 | ABCB1 | Venlafaxine | Efficacy |
| 1447943591 | 3 | rs1045642 | ABCB1 | Agomelatine | Efficacy |
| 1447943608 | 3 | rs1045642 | ABCB1 | Selective serotonin reuptake inhibitors | Efficacy |
| 1452426500 | 3 | rs1128503 | ABCB1 | Antidepressants | Efficacy |
| 1183619312 | 3 | rs11983225 | ABCB1 | amitriptyline; citalopram; paroxetine; venlafaxine | Efficacy |
| 1183619317 | 3 | rs12720067 | ABCB1 | amitriptyline; citalopram; paroxetine; venlafaxine | Efficacy |
| 1444703230 | 3 | rs2032582 | ABCB1 | Fluoxetine | Efficacy |
| 982032743 | 3 | rs2032582 | ABCB1 | clomipramine; lithium; nefazodone; paroxetine; venlafaxine | Toxicity |
| 619523414 | 3 | rs2032583 | ABCB1 | amitriptyline; antidepressants; citalopram; fluvoxamine; paroxetine; sertraline; venlafaxine |
Efficacy |
| 619523422 | 3 | rs2235015 | ABCB1 | amitriptyline; antidepressants; citalopram; paroxetine; venlafaxine | Efficacy |
| 1183619322 | 3 | rs2235040 | ABCB1 | amitriptyline; citalopram; paroxetine; venlafaxine | Efficacy |
| 1183629315 | 3 | rs2235067 | ABCB1 | amitriptyline; citalopram; paroxetine; venlafaxine | Efficacy |
| 1183689585 | 3 | rs28401781 | ABCB1 | citalopram; fluoxetine; paroxetine; sertraline | Efficacy |
| 1183629305 | 3 | rs4148739 | ABCB1 | amitriptyline; citalopram; fluoxetine; paroxetine; sertraline; venlafaxine |
Efficacy |
| 1183629310 | 3 | rs4148740 | ABCB1 | amitriptyline; citalopram; paroxetine; venlafaxine | Efficacy |
| 982031026 | 3 | rs7787082 | ABCB1 | amitriptyline; citalopram; paroxetine; venlafaxine | Efficacy |